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Registration of multi-modal images is one of the challenging problems in image processing nowadays. In this paper, two novel non-rigid registration models are proposed for multi-modality images. In model 1, mutual information of the template and reference images is used as data fitting term with Gaussian curvature regularization. This approach may not give satisfactory results in noisy images or images having bias field. To overcome this drawback, model 2 is proposed which is based on normalized gradient of both template and reference images as a data fitting term instead of mutual information. To get best transformations, both the models are minimized by using Augmented Lagrangian Method. The proposed models can register multi-modality images without effecting edges and other important fine details and are also tested on various medical images like (T1-T2 MRI, PD weighted-T2 MRI) noisy and synthetic images. The proposed models are also tested on a well known free available Brainweb dataset, where they produced satisfactory results. From experimental results, it can be observed that normalized gradient field based model gives better results than mutual information based model. Comparison is done qualitatively and quantitatively through Jaccard Similarity Coefficient.

On Two Algorithms for Multi-Modality Image Registration Based on Gaussian Curvature and Application to Medical Images