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Skin Lesion detection and classification are very critical in diagnosing skin malignancy. Existing Deep learning-based Computer-aided diagnosis (CAD) methods still perform poorly on challenging skin lesions with complex features such as fuzzy boundaries, artifacts presence, low contrast with the background and, limited training datasets. They also rely heavily on a suitable turning of millions of parameters which often leads to over-fitting, poor generalization, and heavy consumption of computing resources. This study proposes a new framework that performs both segmentation and classification of skin lesions for automated detection of skin cancer. The proposed framework consists of two stages: the first stage leverages on an encoder-decoder Fully Convolutional Network (FCN) to learn the complex and inhomogeneous skin lesion features with the encoder stage learning the coarse appearance and the decoder learning the lesion borders details. Our FCN is designed with the sub-networks connected through a series of skip pathways that incorporate long skip and short-cut connections unlike, the only long skip connections commonly used in the traditional FCN, for residual learning strategy and effective training. The network also integrates the Conditional Random Field (CRF) module which employs a linear combination of Gaussian kernels for its pairwise edge potentials for contour refinement and lesion boundaries localization. The second stage proposes a novel FCN-based DenseNet framework that is composed of dense blocks that are merged and connected via the concatenation strategy and transition layer. The system also employs hyper-parameters optimization techniques to reduce network complexity and improve computing efficiency. This approach encourages feature reuse and thus requires a small number of parameters and effective with limited data. The proposed model was evaluated on publicly available HAM10000 dataset of over 10000 images consisting of 7 different categories of diseases with 98% accuracy, 98.5% recall, and 99% of AUC score respectively.

FCN-Based DenseNet Framework for Automated Detection and Classification of Skin Lesions in Dermoscopy Images