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The blood vessels are the primary anatomical structure that can be visible in retinal images. The segmentation of retinal blood vessels has been accepted worldwide for the diagnosis of both cardiovascular (CVD) and retinal diseases. Thus, it requires an appropriate vessel segmentation method for automatic detection of retinal diseases such as diabetic retinopathy and cataract. The detection of retinal diseases using computer-aided diagnosis (CAD) can help people to avoid the risks of visual impairment and save medical resources. This survey presents a comparative analysis of various machine learning and deep learning-based methods for automated blood vessel segmentation in retinal images. This paper briefly describes fundus photography, publicly available retinal databases, pre-processing and post-processing techniques for retinal vessels segmentation. A comprehensive review of the state of the art supervised and unsupervised blood vessel segmentation methodologies are presented in this paper. The objective of this study is to establish a professional structure to familiarize an individual with up-to-date vessel segmentation techniques. Moreover, we compared these approaches to the dataset, evaluation metrics, pre-processing and post-processing steps, feature extraction, segmentation methods, and induced results.

Comparative Analysis of Vessel Segmentation Techniques in Retinal Images