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How was the catalytic performance of the title catalyst influenced and enhanced by the Response Surface Methodology optimized-reaction conditions? Based on our experimental data, the effects of the Response Surface Methodology optimized reaction conditions on the catalytic performance were investigated in this paper. The experimental results show that, the micro alterations of various reaction parameter values resulted in the micro changes of cyclohexane conversion, further causing the positive and negative effects, and resulting in the synergy or the antagonism to cyclohexane conversion. The statistic study via Response Surface Methodology showed that, (1) the size order of the effects of the parameters on cyclohexane conversion was that, the quadratic terms > the mutual interaction terms ≈ the single variable terms; (2) compared to Traditional Optimization Method, Response Surface Methodology could more quickly offer the precise optimum values of reaction conditions. In the five recycle applications of the title catalyst, on average, the catalytic activity and the catalytic efficiency were respectively increased 50% and 25% than those obtained from the Traditional Optimization Method-optimized reaction conditions; (3) compared to the other similar catalysts reported in literatures, the present catalyst was a biomimetic catalyst with the highest Turnover Frequency value ( $6.5\times 10^{5}\,\,\text{h}^{-1}$ ).

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How Did the Response Surface Methodology Optimized Reaction Conditions Influence and Enhance the Catalytic Performance of Nanoprous Chitosan Immobilized Cobalt Porphyrinate