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The title compound, C23H32N2O, adopts an E conformation about the C=N bond. The dihedral angle between the aromatic rings is 25.39 (14)°. One of the tert-butyl groups has rotational disorder, with site occupancies of 0.716 (3) and 0.284 (3). An intramolecular O—H...N hydrogen bond is present, forming an S(6) ring motif

4,6-Di-tert-butyl-2-{(E)-[4-(dimethylamino)phenylimino]methyl}phenol