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In the title compound, C21H16BrFN2O2S, the indole ring system makes dihedral angles of 87.23 (10) and 77.58 (9)° with the fluorobenzene and phenyl rings, respectively. The molecular structure is stabilized by a C—H...O and a C—H...Br intramolecular hydrogen bond, which generate S(6) and S(8) ring motifs, respectively. In the crystal, molecules are linked by C—H...π interactions, forming ribbons propagating along the a-axis direction. Within the ribbons, there are offset π–π interactions present involving inversion-related molecules [intercentroid distance = 3.650 (1) Å]

N-[(3-Bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-4-fluoroaniline