Open AccessLigands in crystal structures that aid in functional characterization
Author(s) -
Speers Anna E.,
Cravatt Benjamin F.
Publication year - 2010
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309110035748
Subject(s) - structural genomics , characterization (materials science) , computational biology , substrate specificity , chemistry , function (biology) , nanotechnology , protein structure , biology , biochemistry , genetics , materials science , enzyme
Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative.