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In the title compound, C 21 H 20 BrNO 5 S, the thio­phene group is located above the mean plane of the indole ring and displays rotational disorder ( i.e.  rotation through 180°). The site occupancy of the major component is 0.902 (2), while that of the minor component is 0.098 (2). In the crystal, pairs of weak C—H⋯O inter­actions link the mol­ecules into centrosymmetric dimers.

1-tert-Butyl 2-ethyl 5-bromo-3-(thiophen-2-ylcarbonyl)-1H-indole-1,2-dicarboxylate