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In the title compound, C 32 H 35 BrN 4 O 3 , the piperazine ring exists in a chair conformation. The quinoline ring system is oriented at dihedral angles of 82.70 (17) and 19.54 (17)° to the phenyl and meth­oxy­phenyl rings, respectively. Weak inter­molecular C—H⋯π inter­actions are present in the crystal structure.

N-[(R)-(6-Bromo-2-methoxyquinolin-3-yl)(phenyl)methyl]-N-[(S)-1-(4-methoxyphenyl)ethyl]-2-(piperazin-1-yl)acetamide