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The title compound, C 23 H 24 O 6 , crystallizes with two independent mol­ecules ( A  and  B ) in the asymmetric unit. The dihedral angles between the benzopyran ring and the α,β-unsaturated ketone unit and between the α,β-unsaturated ketone group and the benzene ring are 9.4 (10) and 12.96 (13)°, respectively, in mol­ecule  A  and 1.40 (17) and 4.44 (17)°, respectively, in mol­ecule  B . The two meth­oxy groups at the  meta  positions of the benzene ring are close to being coplanar with the ring [C—O—C—C = 6.2 (3) and −1.4 (3)° in mol­ecule  A  and −4.2 (4) and 3.7 (3)° in mol­ecule  B ], whereas the third meth­oxy group, at the  para  position, is (+)-anti­clinal with respect to the benzene ring [C—O—C—C = 81.7 (3)°] in mol­ecule  A  and is (−)-synclinal with respect to the benzene ring [C—O—C—C = −103.2 (3)°] in mol­ecule  B . In both independent mol­ecules, the hy­droxy group is involved in an intra­molecular O—H⋯O hydrogen bond.

(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one