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In the title compound, C 21 H 26 N 2 O 2 S, the cyclo­hexane ring adopts a chair conformation. The angle at the methyl­ene bridge linking the pyrimidine and cyclo­hexane rings is 113.41 (13)°. This is in the range considered optimal for maximum activity of non-nucleoside reverse transcriptase inhibitors. In the crystal, mol­ecules are connected into centrosymmetric dimers  via  pairs of N—H⋯O hydrogen bonds.

6-Cyclohexylmethyl-5-ethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one