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In the title compound, C 18 H 24 N 4 O·H 2 O, the piperizine ring adopts a chair conformation and the dihedral angle between the phenyl and pyridine rings is 39.9 (3)°. The comformations of the attachment of the anisole and  N -ethyl­pyridin-2-amine groups to the piperazine ring are +anti­periplanar. An intra­molecular C—H⋯O inter­action occurs. In the crystal, the water mol­ecule links the mol­ecules into chains through O—H⋯N hydrogen bonds. Weak N—H⋯O, C—H⋯N and C—H⋯O inter­actions further stabilize the crystal structure.

N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}pyridin-2-amine monohydrate