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The title compound, C 20 H 25 N 3 O 2 , is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized  via  π–π stacking inter­actions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å.

5-Butylamino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione