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In the title isoquinoline-dione derivative, C(16)H(16)N(2)O(3)S, the piperidine ring in the tetra-hydro-isoquinoline ring system adopts a distorted envelope conformation. The thia-zole ring is essentially planar [maximum deviation = 0.004 (1) Å] and is inclined at a dihedral angle of 31.08 (3)° with respect to the mean plane through the tetra-hydro-isoquinoline ring system. In the crystal structure, inter-molecular O-H⋯O and C-H⋯O inter-actions link adjacent mol-ecules into a three-dimensional extended network. The crystal structure is further stabilized by weak C-H⋯π inter-actions.

4-[(2,4-Dimethylthiazol-5-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione