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The mol-ecule of the title nicotinonitrile derivative, C(22)H(19)BrN(2)O(2), is non-planar, the central pyridine ring making dihedral angles of 7.34 (14) and 43.56 (15)° with the 4-bromo-phenyl and 4-ethoxy-phenyl rings, respectively. The eth-oxy group of the 4-ethoxy-phenyl is slightly twisted from the attached benzene ring [C-O-C-C = 174.2 (3)°], whereas the eth-oxy group attached to the pyridine ring is in a (+)syn-clinal conformation [C-O-C-C = 83.0 (3)°]. A weak intra-molecular C-H⋯N inter-action generates an S(5) ring motif. In the crystal structure, the mol-ecules are linked by weak inter-molecular C-H⋯N inter-actions into screw chains along the b axis. These chains stacked along the a axis. π-π inter-actions with centroid-centroid distances of 3.8724 (16) and 3.8727 (16) Å are also observed.

6-(4-Bromophenyl)-2-ethoxy-4-(4-ethoxyphenyl)nicotinonitrile