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The title compound, C 16 H 20 N 4 O 3 S, adopts an  l -shaped conformation, as seen by the dihedral angle of 76.93 (7)° formed between the two aromatic rings. The most notable feature of the crystal packing is the formation of N—H⋯O and N—H⋯N hydrogen bonds that lead to supra­molecular chains orientated along the  b  axis.

N-(4,6-Dimethylpyrimidin-2-yl)-4-(oxolan-2-ylamino)benzenesulfonamide