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The asymmetric unit of the title compound, 4C 20 H 22 N 4 O 5 ·2C 2 H 6 O·CH 4 O, contains two pyridine-3-carboxyl­ate mol­ecules, one ethanol mol­ecule and one methanol mol­ecule disordered about in a centre of symmetry. The pyridinone ring, the carbamide group and the bicyclic fragment in both independent mol­ecules are planar within 0.03 Å due to the formation of intra­molecular O—H⋯O and N—H⋯O hydrogen bonds. The formation of these latter inter­actions also causes the redistribution of the electron density within the hydroxy­pyridone fragment, with the result that some bonds are elongated compared with values in the literature and some others are shorter. In the crystal phase, the pyridine-3-carboxyl­ate mol­ecules form layers parallel to (010), which are inter­linked through hydrogen bonds mediated by the bridging solvate mol­ecules. A terminal ethyl group in one of the mol­ecules is disordered over two sites of equally occupancy.

Ethyl 5-[(1H-benzoimidazol-2-yl)aminocarbonyl]-4-hydroxy-2-methyl-6-oxo-1-propyl-1,6-dihydropyridine-3-carboxylate–ethanol–methanol (4/2/1)