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The title compound, C 17 H 25 ClN 3 O 3+ ·Cl − ·H 2 O, is a monohydrated hydro­chloride salt of a new derivative of mosapride, which is a pharmaceutical compound possessing gastrointestinal pro-kinetic activity. The chloride anion accepts hydrogen bonds from the NH group of the pyrrolooxazine fused-ring system and from the amine group, and the water mol­ecules form hydrogen bonds that bridge between the chloride anion and the C=O bond of the amide.

3-[(4-Amino-5-chloro-2-ethoxybenzamido)methyl]pyrrolo[2,1-c][1,4]oxazin-5-ium chloride monohydrate