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The title compound, C 15 H 24 N 2 O 4 Si, was prepared by the reaction of (3-acetamido-5-nitro­benz­yl)methanol with  tert -butyl­dimethyl­silyl chloride and is a key inter­mediate in the synthesis of novel nonsymmetrical DNA minor groove-binding agents. There are two independent mol­ecules in the structure, which differ primarily in the rotation about the C—O bond next to the Si atom. Two strong N—H⋯O hydrogen bonds align the mol­ecules into a wide ribbon extending approximately parallel to the  b  axis.

N-[3-(tert-Butyldimethylsiloxymethyl)-5-nitrophenyl]acetamide