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The title compound, amtolmetin guacil, C 24 H 24 N 2 O 5 , is a new gastroprotective non-steroidal anti-inflammatory drug. In the crystal structure, the drug mol­ecule is linked into a one-dimensional structure along the  c  axis by weak N—H⋯O inter­actions between the amide groups. C—H⋯O and C—H⋯π inter­actions influence the packing.

2-Methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetamido}acetate