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In the title compound, C24H28N2O4S, the dihedral angle between the phenol ring and the thiazole ring system is 10.6&#8197;(1)&#176;, and the trimethoxyphenyl group is approximately perpendicular to the thiazole ring, the dihedral angle being 84.7&#8197;(2)&#176;. There is a strong intramolecular hydrogen-bonding interaction between the Schiff base and the hydroxy group

(E)-2-[4-tert-Butyl-5-(2,4,5-trimethoxybenzyl)thiazol-2-yliminomethyl]phenol