Open AccessStructure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression
Author(s) -
West Brandyn R.,
Hastie Kathryn M.,
Saphire Erica Ollmann
Publication year - 2014
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s1399004714007883
Subject(s) - arenavirus , lymphocytic choriomeningitis , nucleoprotein , virology , biology , immunosuppression , viral replication , exonuclease , genetics , virus , microbiology and biotechnology , dna , immunology , polymerase , antigen , cd8
The X‐ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C‐terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three‐dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.