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The miniaturization, integration, and analysis of chemical and biological processes on the nanoliter-scale have currently led to remarkable progress in biotechnology, protein crystallization, and combinatorial chemistry. Aside from having advantages such as reduction of sample volumes and shorter reaction and analysis times, microfluidics is a powerful tool for investigations of soft condensed matter and biological systems. The marriage of microfluidics with spatially resolved microdiffraction provides new opportunities to study time-resolved reaction dynamics as well as non-equilibrium dynamics of biomaterials. The characterization of these complex materials, which are typically liquid-crystalline at ambient conditions, is significantly improved owing to a concurrent orientation during the self assembly process. Moreover, the influence of external stress on the biological materials can be analyzed. Here, we present experiments on the dynamics of the compaction of DNA by linker-histone proteins and artificial polyimine dendrimers.

Combining microfluidics with micro-SAXS for studies of the dynamics of DNA compaction