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1 diet L-Threonine is an indispensable amino acid and under normal conditions is synthesised by microbes from oxaloacetate. Threonine degradation occurs by two major pa thways : -either it is converted by TDH to 2-amino-3-ketobutyrate, w h i c h b y t h e a c t i o n o f 2 a m i n o 3 o x o b u t y r a t e C o A l i g a s e p r o d u c e s g lycine and acetyl CoA. -or alternatively L-serine/ t h r e o n i n e d e h y d r a t a s e converts threonine to NH4 and 2-ketobutyrate and the latter is further metabolized by way of acetyl CoA.

Structural studies of acyl-CoA thioesterase 7 and its role in inflammation