English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

distribution of conformational states represented in the PDB. A systematic review of multiple deposits shows that a single protein is rarely represented by a single structural conformer. This result sheds light on the first link and demands the reformulation of the proteinfolding problem. A vast majority of proteins shows significant number of distinct conformational states with, sometimes large, structural divergence (up to ~24Å). The results suggest that every single protein evolved according to its own optimization principles combining different proportions of rigid (solid-like) and mobile (liquid-like) structural elements. The results suggest further that the optimization process that produced the particular combination of those elements is intricately connected with the function of individual proteins. Therefore, the structural description of the protein, besides the folding class (the architecture represented by the SCOP database), should include the natural structural divergence (width of the distribution) as two main attributes. Additionally, our analysis suggested the principles of functional evolution by use of the Dual Personality sequences (sequences with incomplete representation in the atom records that have distinctive sequence features from regularly folded and intrinsically disordered fragments).

Analysis of the organic X-ray powder diffraction database and its use with pharmaceutical substances