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24 European Crystallographic Meeting, ECM24, Marrakech, 2007 Page s123 Acta Cryst. (2007). A63, s123 agents, anti-Alzheimer drugs, and insecticides. A better understanding of its molecular mode of action thus goes beyond academic interest, and may be beneficial to the design of anti-Alzheimer drugs, antidotes against OP poisoning and novel insecticides. We have solved crystal structures of conjugates with Torpedo californica AChE (TcAChE) of the potent nerve agent, soman. Soman reacts covalently with the active-site serine to form an initial conjugate (the ‘non-aged’ conjugate), that can be reactivated by suitable oximes. This conjugate subsequently undergoes a dealkylation reaction known as ‘aging’, that produce a conjugate that can no longer be reactivated (the ‘aged conjugate’) [1]. X-ray crystallography data collection performed at the ESRF (Grenoble, France), permitted solution of the structure of both conjugates. Since ‘aging’ reaction is fast at room temperature, the crystal-soaking time prior to cryo-cooling had to be reduced to minutes in order to trap the ‘nonaged’ conjugate. The structures obtained supply a structural basis for rational designing of more oxime reactivators that may serve as antidotes of OP intoxication.

Crystallographic study ofE. coliWrbA protein in complex with its flavin cofactor