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Powder crystallography on macromolecules
Author(s) -
Margiolaki I.,
Wright J. P.
Publication year - 2008
Publication title -
acta crystallographica section a
Language(s) - English
Resource type - Journals
eISSN - 1600-5724
pISSN - 0108-7673
DOI - 10.1107/s0108767307043735
Subject(s) - powder diffraction , microcrystalline , macromolecule , crystallography , synchrotron , diffraction , materials science , resolution (logic) , x ray crystallography , protein crystallization , work (physics) , chemistry , crystallization , optics , computer science , organic chemistry , physics , thermodynamics , biochemistry , artificial intelligence
Following the seminal work of Von Dreele, powder X‐ray diffraction studies on proteins are being established as a valuable complementary technique to single‐crystal measurements. A wide range of small proteins have been found to give synchrotron powder diffraction profiles where the peak widths are essentially limited only by the instrumental resolution. The rich information contained in these profiles, combined with developments in data analysis, has stimulated research and development to apply the powder technique to microcrystalline protein samples. In the present work, progress in using powder diffraction for macromolecular crystallography is reported.