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The viewing of crystals in drops has basically stayed the same for the last 70+ years. Now, a novel, new 3D digital videomicroscope system developed specifically for crystallographers will change all that. The presentation will cover the use of this new and exciting technology that is compatible with all known plates types, as well as styles of drop preparation (hanging drop, sitting drop, or under oil). There will also be a discussion regarding the potential advantages of 3D imaging as it relates to presentations, scoring, beam line crystal placement, patent opportunities, documentation, harvesting, and the implementation of the systemwithin the confines of completely automated storage, imaging and scoring systems. In addition, details on how the 3D microscope performs its’ 360° degree rotation and allows the user to view the experiment from all angles without having to move it will also be presented. The uniqueness of the microscope system is evident in the 3Dmovies the user can generate in real time. A variety of movies (with and without crystals) will be shown and analyzed as part of the presentation. With inspection powers from 10 to 7000x, along with a variety of options and adapters, including various 3D rotary head adapters, the system can handle examining large drops; to the small channels found within a microfluidic screening device. Various styles of lighting adapters are also available to help view the crystals and will also be discussed. The microscope has a fully automated stage and software which has been optimized for crystallographers, the details of which will be presented at the conference. Log onto www.fmpharma.com or www.hirox-usa.com to preview examples of the 3Dmovies prior to the ECM 2006 presentation. m02.o03

A novel instrument forin-situX-ray inspection of protein crystals in multi-well plates