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Parasitic protozoa Trypanosoma causes diseases in both human and domestic animals. In human, the disease is characterized by clinical symptoms such as fever, headache, body pain, sleepiness, and immunosuppression. Bioactive substances produced during the infection cause these symptoms, whose molecular mechanisms remain to be elucidated. Prostaglandins (PGs) of 2series are metabolites of arachidonic acid formed by the oxidative cyclization of the central five carbon atoms within this fatty acid. It is well documented that PGD2 is one of the endogenous sleep-promoting substances. PGD 2 and PGE2 play important roles in clinical and pathological manifestations (such as somnolence, immunosupression acute fever, shivering, headache) in mammals. Also, it is often believed that host cells solely produce prostaglandins, which mediate inflammatory responses during infection with parasitic protozoa. Trypanosoma produces PGD 2, PGE2, and PGF2α (PGF2α > PGE2 > PGD2), and releases them in the medium and out of parasitized red blood cells. We crystallized the NADP-dependent prostaglandin F 2α synthase from T. brucei used by the hanging-drop vapour-diffusion method. The crystal was tetragonal system, space group P41212, with unit-cell parameters a = b = 112.3, c = 140.0 Å. The X-ray diffraction data were collected from a crystal to a resolution of 2.8 Å using our home facility at room temperature.

Crystallization and preliminary X-ray diffraction analysis of prostaglandin F2αsynthase fromTrypanosoma brucei

Crystallization and preliminary X-ray diffraction analysis of prostaglandin F_2αsynthase fromTrypanosoma brucei