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A framework is presented for understanding the common character of proteins.Proteins are linear chain molecules. However, the simple model of a polymerviewed as spheres tethered together does not account for many of the observedcharacteristics of protein structures. The authors show here that proteins maybe regarded as tubes of nonzero thickness. This approach allows one to bridgethe conventional compact polymer phase with a novel phase employed by Nature tohouse biomolecular structures. The continuum description of a tube (or a sheet)of arbitrary thickness entails using appropriately chosen many-bodyinteractions rather than two-body interactions. The authors suggest that thestructures of folded proteins are selected based on geometrical considerationsand are poised at the edge of compaction, thus accounting for their versatilityand flexibility. This approach also offers an explanation for why helices andsheets are the building blocks of protein structures.Comment: 30 pages, 5 figure

Colloquium: Geometrical approach to protein folding: a tube picture