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We report both sub-diffraction-limited quantum metrology and quantum enhancedspatial resolution for the first time in a biological context. Nanoparticlesare tracked with quantum correlated light as they diffuse through an extendedregion of a living cell in a quantum enhanced photonic force microscope. Thisallows spatial structure within the cell to be mapped at length scales down to10 nm. Control experiments in water show a 14% resolution enhancement comparedto experiments with coherent light. Our results confirm the longstandingprediction that quantum correlated light can enhance spatial resolution at thenanoscale and in biology. Combined with state-of-the-art quantum light sources,this technique provides a path towards an order of magnitude improvement inresolution over similar classical imaging techniques.

Subdiffraction-limited quantum imaging within a living cell