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We investigate the mechanisms of histone sliding and detachment with astochastic model that couples thermally-induced, passive histone sliding withactive motor-driven histone unwrapping. Analysis of a passive loop or twistdefect-mediated histone sliding mechanism shows that diffusional sliding isenhanced as larger portions of the DNA is peeled off the histone. The meantimes to histone detachment and the mean distance traveled by the motor complexprior to histone detachment are computed as functions of the intrinsic speed ofthe motor. Fast motors preferentially induce detachment over sliding. However,for a fixed motor speed, increasing the histone-DNA affinity (and therebydecreasing the passive sliding rate) increases the mean distance traveled bythe motor.

Peeling and Sliding in Nucleosome Repositioning