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In Phys. Rev. Lett. 128, 137001 (2022), Wang $\textit{et al}.$ address animportant problem in the overdoped cuprates, taking the first steps towardunderstanding the structure of real defects in these materials, in this casethe apical oxygen vacancy, $\mathrm{V}_\mathrm{O}$, that sits immediately abovethe planar Cu. However, the approach taken has some issues, which we outline inthis Comment.

Comment on "Anisotropic Scattering Caused by Apical Oxygen Vacancies in Thin Films of Overdoped High-Temperature Cuprate Superconductors"