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Recent work indicates that twist-bend coupling plays an important role in DNAmicromechanics. Here we investigate its effect on bent DNA. We provide ananalytical solution of the minimum-energy shape of circular DNA, showing thattwist-bend coupling induces sinusoidal twist waves. This solution is inexcellent agreement with both coarse-grained simulations of minicircles andnucleosomal DNA data, which is bent and wrapped around histone proteins in asuperhelical conformation. Our analysis shows that the observed twistoscillation in nucleosomal DNA, so far attributed to the interaction with thehistone proteins, is an intrinsic feature of free bent DNA, and should beobservable in other protein-DNA complexes.

Bend-Induced Twist Waves and the Structure of Nucleosomal DNA