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A mechanistic theory is developed to describe segregation in confinedmulticomponent suspensions such as blood. It incorporates the two key phenomenaarising in these systems at low Reynolds number: hydrodynamic pair collisionsand wall-induced migration. In simple shear flow, several regimes ofsegregation arise, depending on the value of a "margination parameter" M. Mostimportantly, there is a critical value of M below which a sharp "drainagetransition" occurs: one component is completely depleted from the bulk flow tothe vicinity of the walls. Direct simulations also exhibit this transition asthe size or flexibility ratio of the components changes.

Margination regimes and drainage transition in confined multicomponent suspensions