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We study a one-dimensional model of microtubule assembly/disassembly in whichGTP bound to tubulins within the microtubule undergoes stochastic hydrolysis.In contrast to models that only consider a cap of GTP-bound tubulin, stochastichydrolysis allows GTP-bound tubulin remnants to exist within the microtubule.We find that these buried GTP remnants enable an alternative mechanism ofrecovery from shrinkage, and enhances fluctuations of filament lengths. Underconditions for which this alternative mechanism dominates, an increasingdepolymerization rate leads to a decrease in dissociation rate and thus a netincrease in assembly.

Prolonging assembly through dissociation:A self assembly paradigm in microtubules