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DNA denaturation has long been a subject of intense study due to itsrelationship to DNA transcription and its fundamental importance as anonlinear, structural transition. Many aspects of this phenomenon, however,remain poorly understood. Existing models fit quite well with experimentalresults on the fraction of unbound base pairs versus temperature. Yet, thesesame models give incorrect results for other essential quantities. For example,the predicted base pair fluctuation timescales - relevant to transcription -are orders of magnitude different from those observed experimentally. Here, wedemonstrate that nanoscale thermal transport can serve as a sensitive probe ofthe underlying microscopic mechanisms responsible for the dynamics of DNAdenaturation. Specifically, we show that the heat transport properties of DNAare altered significantly and abruptly as it denaturates, and this alterationencodes detailed information on the dynamics of thermal fluctuations and theirinteraction along the chain. This finding allows for the unambiguousdiscrimination between models of DNA denaturation. Measuring the thermalconductance will thus shed new light on the nature of this important molecule.

Driving denaturation: Nanoscale thermal transport as a probe of DNA melting