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Intracellular transport of large cargoes, such as organelles, vesicles orlarge proteins, is a complex dynamical process that involves the interplay ofATP-consuming molecular motors, cytoskeleton filaments and the viscoelasticcytoplasm. The displacements of particles or probes in the cell cytoplasm as afunction of time are characterized by different (anomalous) diffusion regimes.We investigate here the motion of pigment organelles (melanosomes) driven bymyosin-V motors in \emph{Xenopus laevis} melanocytes using a highspatio-temporal resolution tracking technique. By analyzing the mean squaredisplacement (MSD) of the obtained trajectories as a function of the time lag,we show that the melanosomes display a transition between subdiffusive tosuperdiffusive behavior. A stochastic theoretical model is introduced togeneralize the interpretation of our data. Starting from a generalized Langevinequation that explicitly considers the collective action of the molecularmotors we derive an analytical expression for the MSD as a function of the timelag, which also takes into account the experimental noise. By fitting our modelto the experimental data we were able to discriminate the exponents thatcharacterize the passive and active contributions to melanosome dynamics. Themodel also estimates the "global" motor forces correctly. In this sense, ourmodel gives a quantitative description of active transport in living cells witha reduced number of parameters.

Transition to superdiffusive behavior in intracellular actin-based transport mediated by molecular motors