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KIF1A kinesins are single-headed motor proteins which move on cylindricalnano-tubes called microtubules (MT). A normal MT consists of 13 protofilamentson which the equispaced motor binding sites form a periodic array. Thecollective movement of the kinesins on a MT is, therefore, analogous tovehicular traffic on multi-lane highways where each protofilament is theanalogue of a single lane. Does lane-changing increase or decrease the motorflux per lane? We address this fundamental question here by appropriatelyextending a recent model [{\it Phys. Rev. E {\bf 75}, 041905 (2007)}]. Bycarrying out analytical calculations and computer simulations of this extendedmodel, we predict that the flux per lane can increase or decrease with theincreasing rate of lane changing, depending on the concentrations of motors andthe rate of hydrolysis of ATP, the ``fuel'' molecules. Our predictions can betested, in principle, by carrying out {\it in-vitro} experiments withfluorescently labelled KIF1A molecules.

Traffic of single-headed motor proteins KIF1A: effects of lane changing