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The complex dynamics of intracellular calcium regulates cellular responses toinformation encoded in extracellular signals. Here, we study the encoding ofthese external signals in the context of the Li-Rinzel model. We show that bycontrol of biophysical parameters the information can be encoded in amplitudemodulation, frequency modulation or mixed (AM and FM) modulation. We brieflydiscuss the possible implications of this new role of information encoding forastrocytes.

Coexistence of amplitude and frequency modulations in intracellular calcium dynamics