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We report molecular dynamics simulations of the segregation of twooverlapping chains in cylindrical confinement. We find that the entropicrepulsion between the chains can be sufficiently strong to cause segregation ona time scale that is short compared to the one for diffusion. This resultimplies that entropic driving forces are sufficiently strong to cause rapidbacterial chromosome segregation.

Time scale of entropic segregation of flexible polymers in confinement: Implications for chromosome segregation in filamentous bacteria