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In this paper, we extend a model of host-parasite co-evolution to incorporatethe semi-conservative nature of DNA replication for both the host and theparasite. We find that the optimal mutation rate for the semi-conservative andconservative hosts converge for realistic genome lengths, thus maintaining theadmirable agreement between theory and experiment found previously for theconservative model and justifying the conservative approximation in some cases.We demonstrate that, while the optimal mutation rate for a conservative andsemi-conservative parasite interacting with a given immune system is similar tothat of a conservative parasite, the properties away from this optimum differsignificantly. We suspect that this difference, coupled with the requirementthat a parasite optimize survival in a range of viable hosts, may help explainwhy semi-conservative viruses are known to have significantly lower mutationrates than their conservative counterparts

Host-parasite coevolution and optimal mutation rates for semiconservative quasispecies