English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We study a random heteropolymer model with Langevin dynamics, in thesupersymmetric formulation. Employing a procedure similar to one that has beenused in static calculations, we construct an ensemble in which the affinity ofthe system for a native state is controlled by a "selection temperature" T0. Inthe limit of high T0, the model reduces to a random heteropolymer, while forT0-->0 the system is forced into the native state. Within the Gaussianvariational approach that we employed previously for the random heteropolymer,we explore the phases of the system for large and small T0. For large T0, thesystem exhibits a (dynamical) spin glass phase, like that found for the randomheteropolymer, below a temperature Tg. For small T0, we find an ordered phase,characterized by a nonzero overlap with the native state, below a temperatureTn \propto 1/T0 > Tg. However, the random-globule phase remains locally stablebelow Tn, down to the dynamical glass transition at Tg. Thus, in this model,folding is rapid for temperatures between Tg and Tn, but below Tg the systemcan get trapped in conformations uncorrelated with the native state. At a lowertemperature, the ordered phase can also undergo a dynamical glass transition,splitting into substates separated by large barriers.Comment: 19 pages, revtex, 6 figure

Embedding a native state into a random heteropolymer model: The dynamic approach