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Nanoindentation of viral capsids provides an efficient tool in order to probetheir elastic properties. We investigate in the present work the varioussources of stiffness heterogeneity as observed in Atomic Force Microscopy (AFM)experiments. By combining experimental results with both numerical andanalytical modeling, we first show that for small viruses a position-dependentstiffness is observed. This effect is strong and has not been properly takeninto account previously. Moreover, we show that a geometrical model is able toreproduce this effect quantitatively. Our work suggests alternative ways ofmeasuring stiffness heterogeneities on small viral capsids. This is illustratedon two different viral capsids: Adeno Associated Virus serotype 8 (AAV8) andHepatitis B Virus (HBV with T=4). We discuss our results in the light ofcontinuous elasticity modeling.

Stiffness heterogeneity of small viral capsids