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Translation is a key step in the synthesis of proteins. Accordingly, cellshave evolved an intricate array of control mechanisms to regulate this process.By constructing a multi-component mathematical framework for translation weuncover how translation may be controlled via interacting feedback loops. Ourresults reveal that this interplay gives rise to a remarkable range of proteinsynthesis dynamics, including oscillations, step-change and bistability. Thissuggests that cells may have recourse to a much richer set of controlmechanisms than was previously understood.

Translational control of gene expression via interacting feedback loops