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We challenge the interpretation of the di-photon excess recently observed byboth ATLAS and CMS in a two Higgs doublet framework. Due to the largeenhancement necessary to obtain the observed di-photon signal, a large numberof colored and charged vector-like fermions are called for. We find that evenbefore the hypercharge gauge coupling becomes non perturbative, the one loopeffects of these fermions abruptly drive the scalar potential to instability.

Di-Photon excess in the 2HDM: hasting towards the instability and the non-perturbative regime