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Using existing experimental information from K, B and D decays as well aselectroweak precision tests and oblique parameters, we provide constraints andcorrelations on the parameters of the 4X4 mixing matrix for the Standard Modelwith four generations (SM4). We emphasize that some correlations amongst theparameters have important repercussions for key observables. We work with aparticular representation of this matrix which is highly suited for extractinginformation from B-decays. Implications of the resulting constraints for timedependent and semileptonic CP asymmetries for $D^0$, $B^0$ and for $B_s$ arealso given. While we show that the semi-leptonic asymmetries may besignificantly enhanced in SM4 over the SM, there are important constraints andcorrelations with other observables. In this context we suggest that existingdata from B-factories taken on $\Upsilon (4S)$ and $\Upsilon (5S)$, and in therelevant continuum be used to constrain the semi-leptonic asymmetries for$B_d$, $B_s$ as well as their linear combination. Of course, the data from theTevatron and LHCb experiments can provide non-trivial tests of SM4 as well.

Constraining the mixing matrix for Standard Model with four generations: time dependent and semi-leptonic CP asymmetries in $B_d^0$, $B_s$ and $D^0$