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We calculate the form factor f_+(q^2) for B-meson semileptonic decay inunquenched lattice QCD with 2+1 flavors of light sea quarks. We useAsqtad-improved staggered light quarks and a Fermilab bottom quark on gaugeconfigurations generated by the MILC Collaboration. We simulate with severallight quark masses and at two lattice spacings, and extrapolate to the physicalquark mass and continuum limit using heavy-light meson staggered chiralperturbation theory. We then fit the lattice result for f_+(q^2) simultaneouslywith that measured by the BABAR experiment using a parameterization of the formfactor shape in q^2 which relies only on analyticity and unitarity in order todetermine the CKM matrix element |V(ub)|. This approach reduces the totaluncertainty in |V(ub)| by combining the lattice and experimental information inan optimal, model-independent manner. We find a value of |V(ub)| x 10^3 = 3.38+/- 0.36.

The B -> pi l nu semileptonic form factor from three-flavor lattice QCD: A model-independent determination of |V(ub)|