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Pion-induced Drell-Yan processes are proposed as a potential tool to measurethe flavor dependence of the EMC effect, that is, the flavor-dependentmodification of quark distributions in the nuclear medium. Existing pionicDrell-Yan data are compared with calculations using a recent model for nuclearquark distributions that incorporates flavor-dependent nuclear effects. Whileno firm conclusions can yet be drawn, we demonstrate that existing Drell-Yandata seem to imply a flavor dependence of the EMC effect. We highlight howpion-induced Drell-Yan experiments on nuclear targets can access important newaspects of the EMC effect, not probed in deep inelastic scattering, and willtherefore provide very stringent constrains for models of nuclear quarkdistributions. Predictions for possible future pion-induced Drell-Yanexperiments are also presented.

Pion-induced Drell-Yan processes and the flavor-dependent EMC effect