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The Wingless signaling pathway directs many developmental processes in  Drosophila  by regulating the expression of specific downstream target genes. We report here that the product of the trithorax  group gene  osa  is required to repress such genes in the absence of the Wingless signal. The Wingless-regulated genes  nubbin ,  Distal-less , and  decapentaplegic and a minimal enhancer from the  Ultrabithorax  gene are misexpressed in  osa  mutants and repressed by ectopic Osa. Osa-mediated repression occurs downstream of the up-regulation of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless. Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target genes. These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression.

Osa-containing Brahma chromatin remodeling complexes are required for the repression of Wingless target genes